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“Our objective is to understand female reproductive getting older, and why fertility swiftly declines setting up within the mid-30s,” states Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata is effective.

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This allows the oocytes to pause their growth and enter a Keeping sample, which lasts in the mouse’s adulthood. In mice missing PRC1, the oocytes didn’t pause their expansion; as a substitute, they withered and died within a thirty day period, leaving the mice completely infertile.

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“We don’t know the way these cells are maintained for many years,” says Namekawa. “We need to know The trick of the system.

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At this stage, the cell’s DNA is packaged by using a matrix of specialized proteins – leaving it primed for that very important second, a long time later on, when the egg is fertilized and starts rising into an embryo.

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